N,N-Dimethylacetamide for Headspace gas chromatography
| Formula | C4H9NO |
| Chemical formula | CH3CON(CH3)2 |
| Density | ~ 0.94 g/cm3 (20°c) |
| Molar mass | 87.12 g/mol |
| CAS number | 127-19-5 |
| HS Code | 29241900 |
| EC number | 204-826-4 |
| Storage | store at +15 to +25 °c |
| SDS | available |
| RTECS | LQ2100000 |
| R phrase | R 61-E20/21 |
| S phrase | S 53-45 |
| Odour | amine-like |
| Form | liquid |
| Color | colourless to yellow |
| Explosion limit | 1.7 – 11.5 vol % |
| Ignition temprature | 400 °C |
| Solubility in water | freely soluble |
| Flash point | 70 °C |
| Melting point | ~-20°C |
| Boiling point | 165 – 166 °C |
| Vapur pressure | 1.76 hPa (20°c) |
| Viscosity dynamical | 1.02 mPa*s (20°c) |
| Purity | ≥ | 99.8 | % |
| Identity | Conforms | ||
| Evaporation residue | ≤ | 0.03 | mg/l |
| Water | ≤ | 0.05 | % |
| Color | ≤ | 10 | Hazen |
| Every residual solvent of class 1 | ≤ | 1 | μg/g |
| Every residual solvent of class 2 | ≤ | 10 | μg/g |
| Every residual solvent of class 3 | ≤ | 50 | μg/g |
N,N-Dimethylacetamide for Headspace Analysis is a polar aprotic organic solvent used in analytical chemistry, particularly in headspace gas chromatography (HS-GC) applications. It is a colorless, hygroscopic liquid with high boiling point and strong solvent properties, making it suitable for dissolving a wide range of polar and non-polar compounds. In headspace analysis, it is commonly used as a matrix solvent due to its thermal stability and low volatility.
🏭⚗️ Synthesis
N,N-Dimethylacetamide is industrially prepared by reacting dimethylamine with acetic acid derivatives such as acetic anhydride or methyl acetate under controlled conditions. The resulting amide is purified by distillation to obtain high-purity DMAc suitable for analytical and industrial applications, including headspace-grade solvents.
🧪 Applications
N,N-Dimethylacetamide is widely used as a solvent in organic synthesis, polymer processing, and analytical chemistry. In headspace gas chromatography, it is used as a sample diluent or matrix solvent because of its ability to dissolve analytes while remaining stable under elevated temperatures. It is also applied in the production of pharmaceuticals, synthetic fibers, and resins.
⚠️ Safety
N,N-Dimethylacetamide may cause irritation to the eyes, skin, and respiratory tract. Prolonged exposure may affect the liver and other organs. It should be handled with proper laboratory safety measures, including gloves, goggles, and adequate ventilation or fume hood use.
